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| c. 300 BC |
| | The Greek author Theophrastus writes On the History of Plants, the earliest surviving work on botany | |
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| c. 300 BC |
| | Epicurus postulates a universe of indestructible atoms in which man himself is responsible for achieving a balanced life | |
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| c. 270 BC |
| | On the small Greek island of Samos an astronomer, Aristarchus, comes to the startling conclusion that the earth is in orbit round the sun | |
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| c. 250 BC |
| | Archimedes (it is said) leaps out of his bath shouting eureka ('I have found it') when he perceives how to test for relative density | |
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| c. 220 BC |
| | The Greek mathematician Eratosthenes calculates the circumference of the world with the help of shadows and camels | |
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| c. 140 BC |
| | The Greek astronomer Hipparchus is credited with the invention of the astrolabe, measuring the angle of sun or star above the horizon | |
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| c. 130 BC |
| | The Greek astronomer Hipparchus, mapping the stars, observes but cannot explain the precession of the equinoxes | |
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| c. 130 BC |
| | Hipparchus proposes a grid of 360° of latitude and longitude for mapmaking | |
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| 129 BC |
| | Hipparchus completes the first scientific star catalogue, mapping some 850 stars | |
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| c. 150 |
| | Ptolemy writes in Alexandria an encyclopedic account of Greek scientific theory in cosmology, astronomy and geography | |
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